> Rechercher
  CHUV  |  Unité cantonale HPCI  |  Documents  |  Formation et enseignement  |  Calendrier  |  Contacts  |  Liens 
home < CHUV < Collaborateurs Plan du siteImprimer  



Nom Patrick Basset
Titre Dr. ès Sci.
Fonction 1er assistant universitaire
Tél. 021 314 02 68
Adresse Service de médecine préventive hospitalière
IMU 02-218
CHUV
1011 lausanne
e-mail  
Patrick Basset

Research Interests

My research activities concern population genetics, evolutionary biology, and molecular epidemiology using both theoretical and empirical approaches.

My first project has been an attempt to test different models of effective population size using genetically explicit computer simulations and analytical work. Subsequently, my work concentrated on estimating the role different genomic characteristics on the speciation process. In this context, I first tested the effect of chromosomal rearrangements on gene flow in the shrews of the Sorex araneus group. In addition, characterizing patterns of genetic variation within and between closely related species of house mice helped me to identify genomic parameters (e.g. the recombination rate) important for the establishment of reproductive isolation.

Currently, I use population genetic approaches to study the molecular epidemiology of Methicillin-resistant Staphylococcus aureus (MRSA). In particular, the patterns of acquisition of mobile elements important for virulence and/or resistance to antibiotics (e.g. SCCmec) are investigated by analyzing both local and international collections of MRSA isolates.

Biography

2008 – present: postdoctoral fellow – Service of preventive Medicine, Lausanne University Hospital, Switzerland (Dr D.S. Blanc Lab).

2006 – 2007:postdoctoral fellow – Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, USA (Prof. M.W. Nachman Lab).

2001 – 2006:PhD in Life Sciences – Department of Ecology and Evolution, Lausanne University, Switzerland (Prof. J. Hausser Lab).

1995 – 2000:Master in Life Sciences – Lausanne University, Switzerland.

Publications

  1. Yannic G., Basset P., and Hausser J. 2009. Chromosomal rearrangements and gene flow over time in an inter-specific hybrid zone of the Sorex araneus group. Heredity, in press.
  2. Geraldes A., Basset P., Gibson B., Smith K.L., Harr B., Yu H.-T., Bulatova N., Ziv Y., and Nachman M.W. 2008. Inferring the history of speciation in house mice from autosomal, X-linked, Y-linked and mitochondrial genes. Molecular Ecology, 17: 5349-5363.
  3. Basset P., Yannic G., and Hausser J. 2008. Chromosomal rearrangements and genetic structure at different evolutionary levels. Journal of Evolutionary Biology, 21: 842 - 852.
  4. Yannic G., Basset P., and Hausser J. 2008. Phylogeography and recolonization of the Alps by the Valais shrew (Sorex antinorii), inferred with autosomal and sex-specific markers. Molecular Ecology, 17: 4103 - 4118.
  5. Yannic G., Basset P., and Hausser J. 2008. A hybrid zone with coincident clines for autosomal and sex-specific markers in the Sorex araneus group. Journal of Evolutionary Biology, 21: 658 - 667.
  6. Yannic G., Basset P., and Hausser J. 2008. A new perspective on the evolutionary history of Western Sorex araneus group revealed by paternal and maternal molecular markers. Molecular Phylogenetics and Evolution, 47: 237 – 250.
  7. Basset P., Yannic G., Brünner H., and Hausser J. 2007. Using a Bayesian method to assign individuals to karyotypic taxa in shrew hybrid zones. Cytogenetic and Genome Research, 116: 282 – 288.
  8. Basset P., Yannic G., Brünner H., and Hausser J., 2006. Restricted gene flow at specific parts of the shrew genome in chromosomal hybrid zones. Evolution, 60(8): 1718-1730.
  9. Basset P., Yannic G., Yang F., O’Brien C.M., Graphodatsky A.S., Ferguson-Smith M.A.F., et al., 2006. Chromosome localization of microsatellite markers in the shrews of the Sorex araneus group. Chromosome research, 14: 253-362.
  10. Basset P., Yannic G. and Hausser J., 2006. Genetic and karyotypic structure in the shrews of the Sorex araneus group: Are they independent? Molecular Ecology, 15: 1577-1587.
  11. Fivaz F., Basset P., Lugon-Moulin N. and Hausser J., 2003. Postglacial recolonization of the Valais (Switzerland) by the shrew Sorex antinorii: is dispersal sex-biased? A preliminary study. Mammalia 68(2): 253-262.
  12. Basset P. and Hausser J., 2003. Identification of three Sorex species with microsatellite markers. Mammalia 68(2): 245-252.
  13. Basset P., Balloux F. and Perrin N., 2001. Testing demographic models of effective population size. Proc. R. Soc. Lond. B 268: 311-317.


Retour en haut de la page
Dernière modification le 30.07.2009